Insulin impurities and related standards

Insulin is held here as a working collection of 24 reference materials across 24 CAS numbers. 1 of the entries are impurity-type materials of the parent. 9 entries carry a verified structure drawing, a coverage of 38%; the rest are listed without a structure rather than with an unverified one. 9 of them sit in tier A or B, meaning the data behind the page is complete enough to be indexed and quoted directly, while 15 remain tier C and are kept for search coverage. For a peptide the impurity families are the families of synthesis: deletion sequences from incomplete coupling, epimers at the residues whose alpha proton is acidic enough to be lost, oxidation of methionine, and deamidation of asparagine. Asking for the specific impurity by letter and by structure is faster than asking for a percentage of total related substances, because the second question has no single answer. The counts above describe what is actually held rather than what a general catalogue claims, so the group can be quoted directly against a specification.

Sources: DailyMed (US NLM) - INSULIN GLARGINE-ALDY INJECTION, SOLUTION [LANEXA BIOLOGICS, LLC].

9 reference standards related to Insulin held in the RSSE catalogue — pharmacopoeial impurities, non-compendial impurities, metabolites and labelled analogues where available.

In this group: 7 fine chemicals · 1 general reference standard · 1 impurity reference standard. CAS numbers are listed for 9 of 9; 8 entries carry a structure drawing.

On this page

9 reference standards

All entries — structure, identifiers and pack sizes

Butanedioic acid, 1-(1,1-dimethylethyl) 4-(2,5-dioxo-1-pyrrolidinyl) ester

CAS 138833-93-9C12H17NO6

BACK ORDERRS-U103057
Insulin (Pork) (COLD SHIPMENT REQUIRED) (1342300)

CAS 12584-58-6C256H381N65O76S6

MW 5778

BACK ORDERRS-U061062
Insulin Aspart

CAS 116094-23-6C256H387N65O79S6

MW 5832

BACK ORDERRS-I126001
Insulin chain A oxidized ammonium salt from bovine pancreas

CAS 77282-71-4C97H163N29O46S4

MW 2599.8

BACK ORDERRS-I126002
insulin, des-Asn(21)-Cys(20)-2,2,2-trifluoroethylamide(A)-

CAS 110613-05-3C10H8FeGeN2

MW 285.92

IN STOCKRS-Z394BQ2
insulin, des-Asn(A21)-des-Ala(B30)-

CAS 12584-26-8

BACK ORDERRS-I126004
insulin, desoctapeptide-

CAS 39416-70-1

BACK ORDERRS-I126018
tBuO-C20-Glu(AEEA-AEEA-OSu)-OtBu

CAS 1118767-17-1C49H86N4O15

MW 971.22

BACK ORDERRS-U099418
Insulin Icodec Impurity 2(C20-γ-Glu(AEEA-AEEA-OSu)-OH)

CAS 1188328-38-2C41H70N4O15

MW 859.02

BACK ORDERRS-I126003

9 reference standards

Frequently asked

How many Insulin-related reference standards do you hold?

9 standards are listed on this page as of the latest catalogue build. CAS numbers are published for 9 of them and 8 entries carry a structure drawing. The catalogue is extended as new lots are released.

Can you supply an Insulin impurity that is not listed here?

Yes. Non-compendial impurities can be quoted from a structure — a CAS number is not required. Send the structure, a SMILES string or the parent drug substance with your enquiry and we will come back with availability.

What documentation is supplied with Insulin impurities?

Every lot ships with its own certificate of analysis. The certificate records the catalogue number, the batch number, the tests performed, the specification applied and the result obtained for that lot. A safety data sheet is supplied with the shipment.

Do you publish prices or a lead time for Insulin impurities?

No price list is published: quotations are prepared per enquiry, because availability and packing depend on the lot and the quantity you need. Send the catalogue number and the quantity and a technical contact will answer with availability and a quotation.

Cannot find the impurity you need? Non-compendial impurities can be quoted from a structure — a CAS number is not required. Write to sales@rssechem.com.