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Leucovorin impurities and related standards

Leucovorin is held here as a working collection of 8 reference materials across 1 CAS numbers. 1 of the entries are impurity-type materials of the parent, 2 are salt or counter-ion variants and 4 carry a deuterium label and 2 are nitrosamine analogues. 1 entries carry a verified structure drawing, a coverage of 12%; the rest are listed without a structure rather than with an unverified one. 1 of them sit in tier A or B, meaning the data behind the page is complete enough to be indexed and quoted directly, while 7 remain tier C and are kept for search coverage. The labelled members of this group are used as internal standards, which puts the isotopic distribution at the centre of the specification rather than at its edge: the label position and the enrichment have to be stated, and a co-eluting unlabelled fraction changes the result even when the chemical purity looks acceptable. Where the impurity is a chiral species, the enantiomeric ratio belongs on the specification alongside the chemical purity, because an achiral method reports the two together as one peak.

Sources: DailyMed (US NLM) - LEUCOVORIN CALCIUM INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION [GLAND PHARMA LIMITED].

1 reference standard related to Leucovorin held in the RSSE catalogue — pharmacopoeial impurities, non-compendial impurities, metabolites and labelled analogues where available.

CAS numbers are listed for 1 of 1; 1 entry carries a structure drawing.

On this page

1 reference standards

Entry — structure, identifiers and pack sizes

1 reference standards

Frequently asked

How many Leucovorin-related reference standards do you hold?
1 standards are listed on this page as of the latest catalogue build. CAS numbers are published for 1 of them and 1 entry carry a structure drawing. The catalogue is extended as new lots are released.
Can you supply a Leucovorin impurity that is not listed here?
Yes. Non-compendial impurities can be quoted from a structure — a CAS number is not required. Send the structure, a SMILES string or the parent drug substance with your enquiry and we will come back with availability.
What documentation is supplied with Leucovorin impurities?
Every lot ships with its own certificate of analysis. The certificate records the catalogue number, the batch number, the tests performed, the specification applied and the result obtained for that lot. A safety data sheet is supplied with the shipment.
Do you publish prices or a lead time for Leucovorin impurities?
No price list is published: quotations are prepared per enquiry, because availability and packing depend on the lot and the quantity you need. Send the catalogue number and the quantity and a technical contact will answer with availability and a quotation.

Cannot find the impurity you need? Non-compendial impurities can be quoted from a structure — a CAS number is not required. Write to sales@rssechem.com.