Trimipramine maleate impurities and related standards

Trimipramine maleate is held here as a working collection of 13 reference materials across 3 CAS numbers. Within the range, 1 EP-designated impurities are named explicitly. 4 of the entries are impurity-type materials of the parent, 13 are salt or counter-ion variants. 3 entries carry a verified structure drawing, a coverage of 23%; the rest are listed without a structure rather than with an unverified one. 3 of them sit in tier A or B, meaning the data behind the page is complete enough to be indexed and quoted directly, while 10 remain tier C and are kept for search coverage. Forced degradation on the parent tells you which of these materials a method will actually encounter: hydrolytic stress generates the amide and ester cleavage products, oxidative stress generates the N-oxides and hydroxylated analogues, and photolytic stress generates the ring rearrangements. A standard that is not on that list is usually a process impurity, and it is controlled by the route rather than by the formulation. For a laboratory setting specifications, the workable sequence is to fix the impurity list from the monograph and the degradation study first, and only then to source the standards, because the list determines which materials are worth holding.

Sources: DailyMed (US NLM) - TRIMIPRAMINE MALEATE CAPSULE [BRYANT RANCH PREPACK].

3 reference standards related to Trimipramine maleate held in the RSSE catalogue — pharmacopoeial impurities, non-compendial impurities, metabolites and labelled analogues where available.

CAS numbers are listed for 3 of 3; 3 entries carry a structure drawing.

3 reference standards

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  (-)-Trimipramine maleate

  CAS 138283-60-0C24H30N2O4

  MW 410.22

  BACK ORDERRS-Z400UG5

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• 

  (+)-Trimipramine maleate

  CAS 138283-61-1C24H30N2O4

  MW 410.22

  BACK ORDERRS-Z400UG6

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• 

  Trimipramine Maleate Working Standard (Secondary Reference Standard)

  CAS 521-78-8C24H30N2O4

  MW 410.22

  CUSTOM SYNTHESISRS-Z401J4N

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3 reference standards

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